World Player of the Year Cristiano Ronaldo returns for a Real Madrid side otherwise stricken by injuries and suspensions as they look to beat Atletico Madrid for the first time in six meetings this season on Saturday.
Ronaldo completed his two-game ban for kicking out at Cordoba defender Edimar as the European champions sneaked past Sevilla to open up a four-point lead over Barcelona at the top of the table on Wednesday.
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However, victory came at a cost as World Cup star James Rodriguez broke a bone in his right foot that will keep him out for two months, whilst centre-back Sergio Ramos will also be sidelined due to a hamstring problem in the coming weeks.
Left-back Marcelo misses out at the Calderon too after his appeal against his fifth yellow card of the Liga campaign was dismissed on Thursday.
Real boss Carlo Ancelotti is short of defensive options with Pepe also out with a rib injury, but he insisted he has confidence in the inexperienced pairing of Raphael Varane and Nacho in central defence.