The remaining 15,500 seats will go to fighters, sponsors and promoters.
The cheapest ticket for the bout cost £1,000 ($1,500), rising to about £5,000 ($7,500).
The contest between the two has been set since February, but a ticket contract was only finalised this week.
Ticketmaster's website stated no tickets were available only minutes after they went on sale
Tickets officially went on sale on Thursday at 20:00 BST on the MGM Grand's website and Ticketmaster.
But within minutes they appeared on sites such as StubHub - an online marketplace owned by eBay - with the cheapest priced at £3,511 ($5,270).
American Mayweather, 38, and Filipino Pacquiao, 36, are considered two of the best fighters of their generation and the bout, which has been in the pipeline for five years, is set to generate £162m ($250m).
Mayweather has won all 47 of his fights, 26 by knockout, while Pacquiao has a record of 57 wins, five losses and two draws.
[H/T: BBC News]
